當藥苷，獐牙菜苷

Sweroside 
   Sweroside     CAS  14215-86-2            Molecular Weight：358.343         Formula：C16H22O9

Purity:                  HPLC98%
   Appearance：    white   powder
Test Method：    HPLC; Mass;NMR
Usage:                 For laboratory research use only,not for human or diganostic use。
Package              20mg~1g per bottle。
Storage：           Store in a well closed container, protected from air and light.
Prepare and use solutions at the time of testing. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

Plant Origin

This product is a iridoid from Swertiapatens, a gentianaceae plant.

Description

Sweroside (SWE), an iridoid glycoside, is isolated from Lonicera japonIca. It has diverse biological activities, but little is known in human leukemia. Here, our study showed the potential of sweroside as an effective agent against human leukemia using in vitro and in vivo approaches. Sweroside treatment obviously reduced the cell viability in human leukemia cell lines and primary human leukemia cells. 

sweroside presented inhibition of the body pigmentation and tyrosinase activity in zebrafish in vivo model. These results suggest that sweroside isolated from L. japonica may be an effective skin-whitening agent through the regulates the expression of MAP kinase and melanogenic enzymes.

References

• Han XL1, Li JD1, Wang WL1, Yang C1, Li ZY2. Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis. Biomed Pharmacother. 2017 Nov;95:477-486. doi

• Jeong YT1, Jeong SC1, Hwang JS2, Kim JH3. Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis. Chem Biol Interact. 2015 Aug 5;238:33-9. doi: